Here's my, personal, position on injector cc & nozzles size.
background.
There is a limited amount of TIME to inject fuel at any given rpm.
Part of this limitation is a result of the PCM
Part of this limited duration is simply a result of piston speed IN the cylinder.
for example.
at 2500rpm the PCM could allow for @4ms of injector 'on time', below that rpm you could run a longer duration...and above that rpm you would be well suited to run shorter duration.
do not interpret the above statement as you "need" to run that/those injection durations for a given rpm..but this knowledge directly applies to how we build fuel injectors.
I won't give a complete listing of max PW per rpm, as that is proprietary information.
so...arbitrarily.
at (relatively) low rpm you have the option of running extended injection duration
at (relatively) 'high' rpm, you do not have the option of running extended injection duration.
Furthermore, a larger nozzle will have less efficiency than a smaller nozzle. This is simply due to a loss of mechanical atomization as the fuel exits the nozzle.
a small nozzle is going to be easy to tune, will have the ability &/or option of being very clean at low & midrange rpm at the cost of not being able to inject large volumes of fuel at high(er) rpm.
Keep in mind that HOW an injector is BUILT (not simply nozzle size & cc rating) will tremendously affect that injectors performance.
but in short.
a small(er) nozzle would be suitable for stock or near stock rpm.
As engine rpm increases, the mechanical (*and electronic) window of injection opportunity shortens..meaning that the larger nozzle will have the ability to deliver more fuel at higher rpm...but at the cost of poorer atomization.
to put it in perspective...regarding nozzle size.
the stock 94-03 7.3L fuel injector nozzle has 7 holes, each hole with a .0065" orifice.
a stock 6.0L fuel injector nozzle has 6 holes, with each hole approximately .007"
a stock 6.4L injector nozzle has 6 holes, each hole is around .0055"
soooo....just in case someone wasn't sure...
How the injector is built will affect injection pressure & fuel atomization, equally as much as the nozzle orifice size.
Injection pressure & fuel atomization have a littttle bit to do with cleanliness and horsepower, as the common rail engine's have proven.
My recommendation is to determine the engine's operating rpm, based on how the truck/engine will be used, then choose an approximate hp goal...then chose the smallest nozzle that can be tuned for all the various applications. But only if efficiency is at all a concern.
In my experience...
a stock 7.3L nozzle is suitable for up to 385rwhp at/near the factory rpm range.
a 30% nozzle is nicely suited for up to 450rwhp..up to around 3500rpm
larger than that...it seems that injector build quality & tuning are much more integrated than most would think.