well.....lets see. off the top of my head, about the only components that I seldom replace are the turbochargers. otherwise....be ready to buy a few radiators to the tune of 1100 bucks installed. the rest of the cooling system is plagued with problems starting with leaking radiator hoses. the hoses have been updated and have a white end with double orings. but the leaking hoses result in low coolant levels which results in cavitated front covers(coolant in engine oil) and failed horizontal egr coolers (coolant in #8 cylinder resulting in btoken connecting rod and a new engine). YAY!!! Aside from that.... the fuel injectors are very durable and seldom to almost never have issues, unless.....the hp fuel pump has the slightest drop of anything other than diesel fuel pass anywhere near it. in which case, the pump fails sending debris to the injectors requiring the entire fuel system to be replaced to the tune of $6k minimum. And.... lets say you never experience those problems, you still have the common lifter failure, cracked piston, or other bottom end failure requiring shortblock replacement. when you go to have shortblock replaced....they will probably find a cracked head or two which will add another 2 grand to the repair. commonly....internal fuel leaks cause fuel in the oil which builds up in the CAC and then overfuels the engine causing total melt down. the last ten complete engine replacements that I have performed came in at just under 20 grand. most of these engines dont make it past 150k miles and I've never seen one over 200k miles. other than all of that....they run like a bat out of hell....when they are running.