It all depends.....
If you planned to run a good bit of boost, a 45 would be a good choice.
Amazingly, if you wanted to run 50lbs or less, the 45 would be too small....
The lower the boost you want to run, the bigger the charger has to be to still be efficient....
You can't make a blanket statement about compounds and any given charger without also stating the rpm and the boost you plan to run. And in reality, you need to factor in intercooled/non-intercooled, where is it intercooled? First stage, interstage, both stages, only after the second stage......
Because the charger's size depends on the intercooling, and where.
Answer this:
Manifold boost __ psig
Engine rpm for peak power ____ rpm
Intercooling plans ___________
Only then can you determine the relative "fit" of a first stage compressor.
But just shootin from the hip here......if you were running the same basic setup as I am, and you had one HELLUVA good sized wastegate for the second stage, then I'd say the 45 would work well. If you wanted to balance both stages and expect the 45 to still be efficient, you'd likely need to run upward of 70psig boost pressure.