Look the best is going to be the front wheel holders. Thats what I was thinking but if you need your bed space that wont work. My dad has the yakima one for his expedition but he has no other choice haha. They def don't look good to me but they work.
Note, you can't clamp a down hill rig in one as they use 20mm axles, usually without quick releases. I just strap my DH rig in like a dirt bike.
Another option if you want to get fancy is you could mount a roof rack to your bed or to a piece of plywood that you'd then toss in the bed. You can get roofrack holders that don't require wheel removal.
All the cool kids here have Dakine tail gate protector and hang the front wheel out side.
I have been using Thule Fork Down carriers. They were originally for the roof rack on my Landcruiser (RIP). I aquired 1"x1" aluminum tube and fastened three racks to it, cut the alu to the width of the pickup bed so there is less lateral play, and just drop it in. Some ratchet or cam lock straps keeps everthing secure. My old freeride bike had a QR20 so I had an adapter to use the normal racks. My new freeride bike has a 20mm through axle and I haven't gotten an adapter for that yet.